Detailed information about the course
| Title | Measles: from virus to cancer therapeutic |
| Dates | 25-08-2011 |
| Responsable de l'activité | Stefan Kunz |
| Organizer(s) | |
| Speakers | Prof. R. Cattaneo, Mayo Clinic, Rochester MN |
| Description | SUMMARYViral systems can facilitate the identification and characterization of new principles in molecular and cellular biology: for example, our early studies of RNA virus persistence disclosed biased hypermutation and RNA editing. We continue to focus on measles and the related viruses that have a negative strand RNA genome and an envelope. We characterize how receptors bind the viral envelope and trigger membrane fusion. We analyze post-entry processes that counteract innate immunity and promote the transformation of host cells into factories producing almost exclusively virus progeny. To assess the relevance of specific interactions for pathogenesis, we generate viruses with minimal differences from their wild type precursors, and infect natural hosts (primates). Based on the safe and effective live attenuated measles vaccine we develop vectors to deliver additional immunizations safely and without additional costs. We also develop vectors that selectively target and eliminate cancer cells in animal models. Clinical trials based on these vectors are currently ongoing. The first part of the seminar will present data documenting an innovative strategy measles virus has developed to infect its natural hosts. A second focus will be the analysis of the receptor-dependent mechanism triggering fusion of the viral and cellular membranes. Finally, recent progress in the field of cancer therapy with viruses will be reviewed, including clinical trials with several genetically modified DNA and RNA viruses, and the last developments in targeting, arming and shielding. The flanking tutorial will add depth to all three areas of focus: pathogenesis, membrane fusion, and oncolysis.Date: August 25, 2011 Time: 16:00 Location: Lausanne, Centre Hospitalier Universitaire Vaudois et Université de Lausanne (CHUV), Auditoire Tissot, BH08-2 The seminar is open to the entire scientific community AFTERNOON ROUND-TABLE DISCUSSION FOR PhD STUDENTSOrganizer: Professor Roberto Cattaneo Date: August 25, 2011 Time: 14:00-15:30 Location: Lausanne, Centre Hospitalier Universitaire Vaudois et Université de Lausanne (CHUV), Auditoire Samos (PMU), BL08 1148-2 Format: 2 papers to read. The two paper will ba presented by one one student (20-25 minutes presentation). prof. Cattaneo will give a short (5 minutes) presentation to focus the problem. Hashiguchi T. et al., Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM. Nature Structural & Molecular Biology, 18,2, 135-142, 2011. Navaratnarajah CK et al., The head of the measle virus attachment protein move to transmit the fusion-triggering signal. Nature Structural & Molecular Biology, 18,2, 1134, 2011. News & Views, Ollmann Saphire E. & Oldstone MBA., Nature Structural & Molecular Biology, 18,2, 115-116, 2011. The students should be divided in two groups, each group should read both papers, and the News and Views. Students of the "Navaratnarajah" group would meet to discuss the strenght of this paper, and nominate one student to present it. The "Hashiguchi" group would do the same for the other paper. Aftr the two presentations, the "Navaratnarajah" students would poke holes in the "Hashiguchi" paper, and vice-versa. Prof. Cattaneo will give a short (5 min) introduction to focus the problem. |
| Location |
CHUV, Lausanne |
| Credits | 0.25 |
| Information | Speaker: Prof. Roberto Cattaneo, Molecular Medicine Department, Mayo Clinic, Rochester, MN, USA Host: Prof. Stefan Kunz, Fundamental Virology, Institute of Microbiology, Univeristy Hospital Center and University of Lausanne, CH 1011 Lausanne |
| Places | 6 |
| Deadline for registration | 24.08.2011 |
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