Introduction to Protein Structure Analysis and AlphaFold

11 & 12 June 2025

Julia Santiago, Prof., UNIL

Pedro Jímenez-Sandoval, Dr. UNIL

Julia Santiago, Prof., UNIL

Pedro Jímenez-Sandoval, Dr. UNIL

This two-day training session will provide the basics of protein structure determination and how this information is stored in databases and how you can download them and visualize it. We will use AlphaFold to predict protein structures and compare them with real structures. We will also investigate how to find homologous structures via 3D searches, and to design mutants.

The second half of the course will be dedicated to use these tools to your own research question, that you might want to address via structural predictions.

Required skills: Students will need their own laptop with enough memory left to install and operate the softwares.

Software demonstrated:
AlphaFold
COOT
PyMOL

1. > The course will not be targeted for Plant Biologists, even if we use plant proteins as an example. That would be applicable to any person that wants to do protein analysis.

Wednesday 11th:

9h30-12h30 - Introduction into structural analysis and protein chemistry
13h30-16h30 - Visualization and protein analysis tools. Protein models using Alpha Fold. Model interpretation, analysis and design.

Thursday 12th:

9h30-11h30 - Alpha Fold limitations an challenges
11h30-12h30 - Usage of tools in proteins of interest by the students
13h30-16h30 - Usage of tools in proteins of interest by the students

University of Lausanne, Room 201, Amphipôle

Map

Reimbursements for CUSO Students:
Train ticket, 2°class, half-fare from your institution to the place of the activity.

Reimbursement of your travel tickets can be asked online through your MyCUSO. 

Deadline for registration: 30.05.2025

12 places available for CUSO students (4 for CUSO Microbiology)

For cancellations after the Deadline of registration or no show: 50 CHF administrative fees

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