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Title

Accelerated Cardiac and Renal MRI

Author Ibtisam ASLAM
Director of thesis Pr. Jean-Paul VALLEE
Co-director of thesis
Summary of thesis Magnetic Resonance Imaging (MRI) is a non-ionizing and non-invasive medical imaging modality which can provide an important quantitative and anatomical information of the examined body part. There is a strong link between cardiac and renal pathology especially in chronic kidney disease patients who mainly died from cardiac failure. MRI has a strong potential to improve the diagnostic and monitoring of such patients. However, a combined cardiac and renal MRI exam is currently not performed due to long MR scan time. Over the past several years, developments in scanner hardware and software have enabled the fast MR imaging acquisition which are extremely useful in various clinical and research application. Dynamic MRI requires fast data acquisition to provide an appropriate combination of spatio-temporal resolution, and volumetric coverage for clinical studies. Golden Angle (GA) Radial acquisition is fast and robust non-Cartesian data acquisition scheme that continuously acquire the data by providing approximately uniform coverage of k-space with lesser acquisition time as compared to conventional acquisition schemes. This GA data is can be sorted offline into multiple time frame to get a desired temporal resolution. A further advantage is that corrupted data lines, for instance due to movement, can be removed and the reconstruction methods applied to maintain the desired image quality. Diffusion-Weighted Magnetic Resonance Imaging (DWI or DW-MRI) is also a noninvasive method sensitive to local water motion in the tissue. DWI uses a specific MRI pulse sequences as well as software that generates images from the resulting data. The thesis work will focuses on the “Accelerated Cardiac and Renal MRI” to explore the relationship between the heart and the kidney. My objective will be to develop some new MR Image reconstruction algorithms to reduce the MR scan time for both the GA cardiac MRI and renal DWI with motion correction especially in renal DWI as well as working on the optimization of a multiparametric Cardiac and Renal MR acquisition protocols to improve the diagnosis.
Status beginning
Administrative delay for the defence
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