CUSO Biology Symposium 2022 II: «Bioinformatics» (SIB)

30 June - 1 July 2022

Dr Grégoire Rossier, SIB

Dr. Laurent Falquet
Prof. hon. Philipp Bucher
Dr. Mario Iurlaro
Dr. Guido van Mierlo

A 2-day workshop will follow the CUSO Biology Symposium on epigenomics. It will be a bioinformatics training on epigenomics data, DNA methylation, histone modification and chromatine re-arrangement.

In this workshop we will try to have continuity with the symposium, on a more applied and bioinformatics side.

Day 1: General introduction to the data for epigenomics. DNA Methylation: ½ for prok and ½ for Euka DNA methylation (bisulfite)

Day 2: Histone modification and chromatine re-arrangement (mainly eukaryotes) (½ day) questions, participants projects, (½ day)

Please note that registration to the two parts of the Symposium has to be done separately:

For the first part: CUSO Biology Symposium 2022 I 'Advances in Epigenetics and Epigenomics'

For the second part: CUSO Biology Symposium 2022 II: 'Bioinformatics' (SIB)

Program:

Day 1: June 30th 9h00-12h30 / 13h30-17h00

• Morning : General introduction to the data for epigenomics

Coffee break 10h40-11h00

• Morning : Prokaryotic DNA methylation (PacBio, etc.) (Laurent Falquet)

• Afternoon: Eukaryotic DNA methylation (bisulfite sequencing and/or EMseq) (Mario Iurlaro)Coffee break 15h20-15h40

Day 2: July 1st 9h00-12h30 / 13h30-17h00

• Morning: Histone modification and chromatine re-arrangement (Guido Van Mierlo)
Coffee break 10h40-11h00

• Afternoon : Cancer epigenomics (Philipp Bucher)
Coffee break 15h20-15h40

Overview

Epigenetics modifications are important modifications of the DNA or the chromatin that affect the bacteria and higher eukaryotes. These modifications can be transmitted from generation to generation, carrying information affecting the gene expression in the off-springs. Current next generation sequencing (NGS) technologies allow for the detection of those modifications at the genome level introducing the «epigenomics». In this workshop we will explore the bioinformatics methods available for studying these data. Since these can be divided in two main categories, DNA methylation on the one hand and chromatin modifications on the other hand, the workshop will reflect this with a first day dedicated to DNA methylation analysis both in prokaryotes and in eukaryotes. The second day will focus on the chromatin modifications (histones and other proteins) in normal and cancerous tissues.

This workshop is coupled with the symposium Advances in Epigenetics and Epigenomics that is going to take place the first 3 days of this week (27-29 June 2022). Please note that although at the same location, these are two independent events, with separate registrations.

Audience

This course is addressed to life scientists who want to learn analysis related to epigenetics modifications.

Learning outcomes

At the end of the course, the participants are expected to:

• have learned about DNA methylation data analysis using R packages and web tools.
• have learned about analysis of chromatin modifications using R packages and web tools.

Prerequisites

Knowledge / competencies

• basic knowlege of epigenetic processes
• basic knowledge of command line (UNIX)
• basic knowledge of R

Technical

You are required to have your own computer with R/RStudio installed, as well as packages to be installed in advance, and that will be communicated to the participants on due time.

Schedule - CET time zone

**Day 1

• Short general introduction about epigenomics data.
• Prokaryotic DNA methylation (lecture & hands-on).
• Eukaryotic DNA methylation (lecture & hands-on).

**Day 2

• Histone modification and chromatine re-arrangement.
• Cancer epigenomics.

Venue and Time

This workshop will take place at the Centre de conférences et de séminaires, Caux Palace, above Montreux.

Additional information

Coordination: Grégoire Rossier (SIB), Corinne Dentan (StarOmics).

You are welcome to register to the SIB courses mailing list to be informed of all future courses and workshops, as well as all important deadlines using the form here.

SIB abides by the ELIXIR Code of Conduct. Participants of SIB courses are also required to abide by the same code.

For more information, please contact [email protected].

Caux (VD)

Map

The course is organized in collaboration with the CUSO programs of Molecular Plant Sciences, StarOmics, Ecology & Evolution and Microbiology.

Expenses:

CUSO Participants will be asked a fee of CHF 30.- to pay before June 1st at the latest. Bank details will be sent in the confirmation e-mail.

Reimbursements for CUSO StarOmics students:
- Train ticket, 2°class, half-fare from your institution to the place of the activity.

NEW from 2021: Reimbursement of your travel tickets can be asked online through your MyCUSO. See HERE for the procedure.
For any question concerning reimbursement please contact the CUSO StarOmics coordinator Corinne Dentan

Other CUSO Students: Please contact the coordinator of your Program.

For non-CUSO participants: CHF 100.-/day + hotel/catering expenses.

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