Detailed information about the course

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Systems Toxicology


15 October

Lang EN Workshop language is English

Dr. Sten IlmJarv, UNIGE


Dr. Sten Ilmjärv, University of Geneva
Dr. Olivier Sorg, University of Geneva
Dr. Vincent Jaquet, RE.A.D.S Unit, University of Geneva,
Mr. Jerven Bolleman, Swiss-Prot, Swiss Insitute of Bioinformatics
Dr. Rex FitzGerald, Swiss Centre for Applied Human Toxicology


Systems toxicology is a cross-disciplinary scientific domain, that aims to understand the mechanisms of substance interactions with biological components in a living system. It combines classical toxicology with computational modelling and advanced analytical tools where large-scale data are used to simulate and predict adverse outcomes. This project intends to give an overview of different aspects of systems toxicology ranging from identifying relevant resources and technologies for data acquisition, to describing toxicological pathway concepts.



9:30 – 10:00

Introduction to the course

10:00 – 11:15

Systems Toxicology in practice: analysis of the Yushchenko case

11:15 – 12:15

Toxicity in in-vitro drug development


Lunch break

13:40 – 15:00

Compound information, how and where to find it

15:00 – 16:00

RDF, SPARQL and using other people's data

16:00 – 17:00

Regulatory considerations in Systems Toxicology

Systems Toxicology is a one-day course that covers the cross-disciplinary scientific domain of Systems Toxicology. A domain that aims to understand the mechanisms of substance interactions with biological components in a living system. We will introduce various aspects of Systems Toxicology including a real-life case of human poisoning, namely of Victor Yuschenko. We will also cover the design and assay development for in-vitro drug toxicity testing and conduct a visit to an assay development and screening facility (READS) where a lot of novel and interesting data is being produced. Also, since a lot of data already exists, we will also give an overview of available public databases, how to navigate compound related data and how to gain access to available data using semantic web technologies. The day will finish with a presentation on regulatory considerations in Systems Toxicology that is the guarantor of safer drugs, safe environment and food.


UNIGE, CMU 8th floor (B08.2225A) in the new building




Audience: No specific perquisites are required but curiosity and basic understanding in biology and some experience in data research will be helpful.

Objectives: At the end of the course, the participant will have a better understanding of different domains within systems toxicology.

Minimum number of participants: 6


Reimbursements for CUSO StarOmics students

Train ticket, 2°class, half-fare from your institution to the place of the activity.
NO reimbursement for your meal expenses

Reimbursement form attached with original tickets has to be sent to the StarOmics coordinator Corinne Dentan at University of Lausanne, Centre Intégratif de Génomique, Le Génopode, 1015 Lausanne.

For any question concerning reimbursement please contact the CUSO StarOmics coordinator Corinne Dentan.


CUSO PhD students: through your MyCUSO account.

External participants (non-CUSO PhD students, post-docs, etc...): use the icon "registration" at top of page and the last gray box "non-CUSO student" ("personne hors myCUSO"). A little financial participation may be requested.



Deadline for registration 15.10.2019

Sten Ilmjärv, PhD


Tel: 022 379 41 45

Mail: sten.ilmjarv(at)unige(dot)ch


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