[REPORT À 2021] GWAS and Beyond

Postponed in 2021

Prof. Sven Bergmann, UNIL
Prof. Olivier Delaneau, UNIL

Prof. Sven Bergmann, UNIL
Prof. Olivier Delaneau, UNIL
Prof. Jacques Fellay, EPFL
Prof. Zoltán Kutalik, UNIL

THE COURSE HAS BEEN POSTPONED.

THE NEW DATES WILL BE ANNOUNCED LATER DURING THE YEAR.

We will start with a quick introduction to Genome-wide association studies (GWAS), including data generation (genotyping/sequencing/imputation) and study design. After this we'd focus on more advanced topics, including fine-mapping of GWAS signals, Mendelian randomisation, GWAS with molecular traits, such as gene expression, epigenetics and metabolomics data, the mapping of association signal onto genes or pathways, and how association signal at different levels can be integrated.

Participants are expected to have some coding experience (preferably in R and bash) and basic knowledge in statistics.

The course will include both interactive presentations and hands-on sessions where real data will be analysed under our supervision.

Thursday

Arrival & Coffee from 09:30

Thursday morning 10:30-12:00 (Sven Bergmann/Olivier Delaneau):

Quick introduction to Genome-wide association studies (GWAS), including data generation (genotyping/sequencing/imputation) and study design. Regression and other tests. Multiple Hypotheses testing, Manhattan and QQ plots etc.

Lunch break 12:00-13:30

Thursday early afternoon 13:30-14:30 (Zoltan Kutalik)

Heritability estimation.

Break 14:30-15:00

Thursday afternoon 15:00-16:30 (Olivier Delaneau)

Fine-mapping of GWAS signals, eQTL, integration of epigenetics.

Thursday late afternoon 17:00-18:00 (Sven Bergmann)

Mapping of association signal onto genes or pathways, network analysis.

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Friday

Lunch break 12:00-13:00

Friday early afternoon 13:00-14:30 (Zoltan Kutalik)

Causality and Mendelian randomisation.

Break 14:30-15:00

Friday late afternoon 15:00-16:30 (Jacques Fellay)

Translational aspects of GWAS: use of genetic variants in personalised medicine and epidemiology.

16:45: Joint discussion Quo vadis GWAS? / Feedback

Eurotel Victoria, Les Diablerets

Fees:

Free for PhD students of StarOmics. Please note that a guarantee of 100 CHF will be asked to PhD students of StarOmics. This guarantee will be given back after the workshop.

All other participants: please contact us before to have the conditions

Reimbursement:

PhD students of StarOmics are eligible for reimbursement of incurred travel expenses by train (half-fare card, and 2nd class). Please send the original tickets (no copies, except for the general pass) with the reimbursement form to:

Corinne Dentan
Centre Intégratif de Génomique
University of Lausanne
Le Génopode
1015 Lausanne

CUSO PhD students: through your MyCUSO account.

External participants (non-CUSO PhD students, post-docs, etc...): use the icon "registration" at top of page and the last gray box "non-CUSO student" ("personne hors myCUSO").

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