Description |
The aims of this biodiversity bioinformatics course are to (i) explore key evolutionary concepts, (ii) examine different methodological approaches, and (iii) gain hands-on experience in comparative genomic analyses, with an emphasis on characterising protein-coding gene evolution and function across multiple animal genomes, both from model and non-model species.
This course will focus on concepts and methods for the orthology and paralogy of protein-coding genes, complemented by practical examples of how comparative genomics approaches can be applied to investigate biological and/or evolutionary questions. It will be structured with lectures in the mornings followed by hands-on sessions in the afternoons. This course is aimed at PhD students, postdoctoral and other researchers in the life sciences who are planning how to proceed with comparative genomics analyses to investigate biological or evolutionary questions of importance to their study system, particularly to leverage comparative genomics tools and resources to characterise the gene repertoires of their non-model species. Learning outcomes At the end of the course, participants should be able to:
- Interpret phylogenetic trees and sequence alignments
- Infer orthologs and paralogs using graph and tree-based methods
- Design and implement comparative analyses to interrogate genomics data, e.g. phylogenomics or gene family dynamics.
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