Detailed information about the course
Title | Dual use of highly pathogenic microbes |
Dates | December 9, 2014 |
Lang | Workshop language is English |
Responsable de l'activité | Stefan Kunz |
Organizer(s) | Prof. Stephen Leib, Spiez Laboratory Dr. Marc Strasser, Spiez Laboratory Dr. Oliver Engler, Spiez Laboratory Prof. Stefan Kunz, University Hospital Center Lausanne Dr. Sylvia Rothenberger, Program Coordinator CUSO |
Speakers | Dr. Urs Pauli Institute of Virology and Immunoprophylaxis, Mittelhäusern Dr. Cedric Invernizzi Bundesamit für Bevölkerungsschutz Prof. Pascal Meylan Lausanne University Hospital and University of Lausanne |
Description | CONTENT OF THE WORKSHOPPathogenic viruses and bacteria that cause incurable diseases with high mortality in humans and animals represent a major challenge for current microbiology research. Based on their disease potential and biological properties, accidental or intentional release of such highly pathogenic microbes represents a serious threat for human populations and agriculture. This CUSO workshop organized by LABOR SPIEZ will cover basic concepts of biological risk evaluation and in particular address the important problem of “dual use” of highly pathogenic microbes. The goal of this workshop is to sensitize the awareness of our Ph.D. students for biological risks and the “dual use” problematic they may encounter during their research activity in microbiology. This will be achieved by combining presentations on the basic concepts of biosafety combined with an interactive exercise in which students will evaluate a microbiology research project under the aspect of biological risk assessment and “dual use” problems with the help of biosafety experts
The first part of the workshop (morning session) will provide the basic concepts of biosafety and biological risk evaluation for human and animal pathogens. This will be followed by a talk highlighting the important problem of “dual use” of pathogenic microbes and cover existing guidelines and legislation.
The afternoon session will consist of three parallel interactive breakout sessions in which biosafety experts will work with students on different biosafety aspects of a concrete microbiology research project, including biological risk evaluation, the challenge of biosafety associated with animal pathogens, and the problem of “dual use”. Each breakout session will be coached by two biosafety experts and include a maximum of four groups of two Ph.D. students each. The students will receive the description of a specific research project in microbiology together with a research article and a more general review on the topic from the experts at least two month before the workshop. Topics will include the study and the generation of novel pathogenic microbes that are a potential threat for humans, agriculture, and/or the environment. The students will prepare a draft of a presentation of their project with particular consideration of biosafety issues. At the meeting ample time (2 hours) will be allocated for interactive work with the biosafety experts to prepare a final short presentation (8 minutes of presentation + 4 minutes of discussion). In the following interactive session, the students will present their projects to the experts and the other participants of the breakout session, who will evaluate the presentations and give feedback. PROGRAM9:30 -10:00 Welcome Coffee 10:00 Presentation of the program
MORNING SESSION
10:10 – 10:55 Basic concept of biosafety Prof. Pascal Meylan, Lausanne University Hospitaland University of Lausanne
10:55 – 11:30 Biosafety in agriculture and animals Dr Urs Pauli, Institute of Virology and Immunoprophylaxis, Mittelhäusern
11:30 – 12:05 The problem of “dual use” of highly pathogenic microbes Dr. Cedric Invernizzi, Bundesamit für Bevölkerungsschutz
Lunch: 12:10 – 13:15
AFTERNOON SESSION
13:15 – 17:00 Breakout sessions
Session 1: Biosafety risk evaluation
Session 2: Biosafety challenges of animal pathogens
Session 3: The risks and problems of “dual use”
13:15 – 15:15 Preparative work of students with experts in groups
Coffee Break
15:30 -17:00 Presentation of projects with round-table discussion
17:00 Conclusion of Workshop
FlyerSession 1: Biosafety risk evalutation: Prof. Pascal Meylan & Prof. Stefan KunzRS 814.912 Ordonnance du 9 mai 2012 sur l’utilisation des organismes en milieu confiné (Ordonnance sur l’utilisation confinée, OUC)Meylan Project 1: Group A streptococcus expressing S.aureus pigment1 Project description_Meylan11 Publication_project_Meylan11 Background project Meylan1Meylan Project 2: production of a Botulineum neurotoxin vaccine candidate2 Project description_Meylan22 Publication_project_Meylan2a2 Publication_project_Meylan2b2 Background project Meylan2Kunz project 1: A highly pathogenic emerging virus: Sin Nombre Hantavirus1 Project description _Kunz11 Background_project_Kunz11 Publication_project_Kunz1Kunz Project 2: Therapy for Ebola virus disease with monoclonal antibodies (ZMapp)2 Project description_Kunz22 Background_project_Kunz22 Publication_project_Kunz2a2 Publication_project_Kunz2bSession 2: Biosafety challenges of animal pathogens: Dr. Urs PauliBackground informationDocument 1Document 2Document 3Case study N°1: Classical Swine fever1_case study 1-description research project1_Fact sheet_CSF1_Ruggli_20091_Diaz-de-Arce_1999Case study N°2: H2N22-case study 2-description research project2_Fact sheet_Influenza2_MSDS_Influenza2_Kilbourne_2012_review2_Torremorell_2012Case study N°3: Foot and Mouth disease3_Case study 3- description of research project3_Fact sheet_FMD3_Alves_2009Case study N°4: Rinderpest4_Case study 4-research project description4_Fact sheet_Rinderpest4_Beauvais_20134_Normile_20104_McCullough_1996Session 3: The risks and problems of "Dual use": Dr. Cédric InvernizziDual use case studies: GENERAL INFORMATION and description of the cases
Background information
Case study N°1: The mousepox case study-How to render a vaccine ineffective1 Background information1 PublicationCase study N°2: The vaccinia case study-How to render a vaccine virulent2 Background information2 PublicationCase study N°3: The 1918 influenza case study-How to revive an extinct pandemic pathogen3 Background information3 Publication
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Location |
Labor Spiez, Spiez, BE |
Map | |
Credits | recommanded: 1 ECTS |
Information | |
Places | 20 |
Deadline for registration | 01.12.2014 |