Functions of histone deacetylases in Schwann cells during manintenance and regenearation

Histone deacetylases (HDACs) are key transcriptional regulators that control gene expression by remodeling chromatin and modifying the activity of transcription factors. There are 18 known mammalian HDACs, subdivided into four classes. Using mouse genetics, we have shown that the two class I HDACs HDAC1 and HDAC2 are crucial for survival and myelination of Schwann cells, the myelinating glia of the peripheral nervous system (PNS), and for maintenance of peripheral nerve integrity in adults. Our current aim is to understand whether and how HDACs can influence the regeneration process in Schwann cells. Our data suggest important functions of HDACs in PNS regeneration.