Epidemiology of invasive and co-colonizing S. pneumoniae serotypes and the role of the capsular thickness.
|Director of thesis||Dr. Markus Hilty|
|Co-director of thesis||Dr. Vincent Perreten|
|Summary of thesis||
The first part of the thesis focuses on the analysis of co-colonisation of Streptococcus pneumoniae within the upper airways/nasopharynx using next generation sequencing (NGS) methods. Here, we hypothesize that using MinION sequencing will result in rapid identification of pneumococcal co-colonization in nasopharyngeal swab (NPS) samples of healthy infants (less than 1 year old) enrolled in the Basel Bern Infant Lung Development (BILD) cohort. We aim to observe a more complete picture of circulating serotypes by including these results with epidemiological analyses.
The second part of the thesis deals with the involvement of arc operon genes of the ADS in capsule thickness differences among different pneumococcal strains. Given limited data on the roles of arcABCDT genes on virulence of the pneumococcus, we hypothesize that these genes influence capsule thickness differences among different strains that could be serotype dependent.
|Administrative delay for the defence||2020|