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Title

Implications of APOBEC3 in genome stability. Identification of sensitivity and resistance genes to bleomycin, in the context of Hodgkin's lymphoma.

Author Daniel Constantin
Director of thesis Christian Widmann
Co-director of thesis
Summary of thesis The APOBEC3 family of proteins has been implicated in innate antiviral defense, however several members of this family have been shown to induce mutations in mammalian cell genomes, we are investigating this phenomenon in more detail. The second project consists of CRISPR/Cas9 genome-wide screening for resistance/sensitivity genes in Hodgkin's lymphoma cells.
Status
Administrative delay for the defence
URL https://www.unil.ch/physiologie/en/home/menuinst/groupes-de-recherche/christian-
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