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Title

Discovery of long non-coding RNAs in cancer using CRISPR/Cas9

Author Nuria Bosch
Director of thesis Rory Johnson
Co-director of thesis William Keyes
Summary of thesis The main aim of my project is to study long non-coding RNAs role in cancer using CRISPR/Cas9 based tools. On one side, I will work on the improvement of existing CRISPR/Cas9 based systems for genomic functional analysis, focusing on lncRNAs. On the other side, I will apply these tools to knock-out lncRNAs candidates that have been bioinformatically predicted to be cancer drivers and study the phenotypic effect on specific cancer cell lines.
Status
Administrative delay for the defence
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