Structure-function analysis of disaggregating chaperones in yeast
|Director of thesis||Prof. Pierre Goloubinoff|
|Co-director of thesis|
|Summary of thesis||
Specifically, I am working on the two disaggregase machineries that co-exist in the yeast cytosol, Hsp100/70 and Hsp104/70 and on their interactions with the J-domain proteins Sis1 and Ydj1 and various misfolded substrates. The goal is to better understand the functional and mechanistic differences between the two systems.
|Administrative delay for the defence|