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Title

Structure-function analysis of disaggregating chaperones in yeast

Author Mathieu Rebeaud
Director of thesis Prof. Pierre Goloubinoff
Co-director of thesis
Summary of thesis Specifically, I am working on the two disaggregase machineries that co-exist in the yeast cytosol, Hsp100/70 and Hsp104/70 and on their interactions with the J-domain proteins Sis1 and Ydj1 and various misfolded substrates. The goal is to better understand the functional and mechanistic differences between the two systems.
Status on-going
Administrative delay for the defence
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