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Title

Structure-function analysis of disaggregating chaperones in yeast

Author Mathieu REBEAUD
Director of thesis Prof. Pierre Goloubinoff
Co-director of thesis
Summary of thesis

Specifically, I am working on the two disaggregase machineries that co-exist in the yeast cytosol, Hsp100/70 and Hsp104/70 and on their interactions with the J-domain proteins Sis1 and Ydj1 and various misfolded substrates. The goal is to better understand the functional and mechanistic differences between the two systems.

Status middle
Administrative delay for the defence
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