Detailed information about the course

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Growth Control With and Without Antibiotics - Do Bacteria Care?


12 November 2018

Responsable de l'activité

Patrick Viollier


Prof. Patrick Viollier, UNIGE

Dr. Laurent Falquet, UNIFR


4 external speakers (to be announced)


The focus of this one-day symposium will be on antibiotic (hetero)resistance, tolerance and stress adaptation by toxins and other mechanisms in various bacterial model systems and important human pathogens. The symposium will potentially also deal with new antibiotic development and therapies, including siderophore-beta-lactam conjugates, colistins, new drugs and combinatorial treatment of old drugs.


Session I: Heteroresistance (9h -10:30h):


· Jan-Willem Veening (University of Lausanne,CH, 30 min):
"Heteroresistance in the human pathogen Streptococcus pneumoniae"


· Yannick Charretier (Hôpitaux Universitaires de Genève, CH, 30 min): "Mechanisms of (hetero)-resistance to colistin in Acinetobacter baumannii"


· Adriana Renzoni (Hôpitaux Universitaires de Genève, CH, 30 min):
"MazF toxin: a magic potion for bacterial sleeping?"


Session II: Efflux (11h – 12:30h)


· Jürg Dreier (Basilea Pharmaceutica, CH, 30 min):
"RND Efflux Pumps in Gram-negative Bacteria from an Industry Perspective"


· Sean Murray (Cal State Northridge University, USA, 30 min):
"Pleiotropic phenotypes resulting from overexpression of a bacterial efflux pump"


· Coralie Fumeaux (Harvard Medical School, USA, 30 min):
"Crosstalk between antibiotic resistances in Pseudomonas aeruginosa"


Session III: TA systems (14h -15:30h):


· Laurent Falquet (University of Frbourg, CH, 30 min):
"TASmania: a bacterial Toxin-Antitoxin Systems database"


· Pierre Genevaux (University of Toulouse, FR, 30 min):
"Toxin-Antitoxin Systems in Mycobacterium tuberculosis"


· Laurence van Melderen (University of Bruxelles, BE, 30 min):
"Toxin-antitoxin systems: why so many, what for?"


Session IV: New drugs (16h -17:30h):


· Nicolas Jacquier (Centre Hospitalier Universitaire Vaudois, CH, 30 min):
"Investigation of the antibacterial effect of an anticancer peptide"


· Thilo Köhler (University of Geneva, CH, 30 min):
"Vectorizing drugs with siderophores to overcome the outer membrane barrier of Gram-negative bacteria"


· 2 Short talks from students


Apéro and dinner (18h-21h)





Deadline for registration 11.11.2018
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