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Genetic subtypes of obesity

Author Jonathan SULC
Director of thesis Zoltán Kutalik
Co-director of thesis Bogdan Draganski
Summary of thesis

Their is a large amount of inter-individual variance in terms of response to obesogenic environmental factors. Indeed, individuals exposed to the same environment may have wildly different phenotypes in terms of body fat content and distribution, and disease risk. Although many SNPs have been linked to changes in body mass index (BMI) and waist-to-hip ratio (WHR), our understanding of the factors underlying these differences is hazy at best.

In this research project, we aim to determine genetic subtypes of obesity characterized by differences in susceptibility to obesogenic environmental factors, body fat distribution, and health outcomes. The identification of the genetic factors defining such subtypes would lead to greater possibilities of personalized intervention in subjects at risk of obesity and obesity-related diseases.

Status beginning
Administrative delay for the defence