The Search for Selection

6-10 September 2021

Jérôme Goudet

Prof. Jérôme Goudet, UNIL

Prof. Bruce Walsh, University of Arizona, US

A vast number of approaches have been suggested in the search for selection, ranging from genomic‐based signatures of recent or ongoing selection, tests based on either excessive amounts or nonrandom patterns of divergence (in both fossil sequences and with functional genomics data) and the more classical Lande‐Arnold fitness estimates (direct association of phenotypic values with fitness estimates) and their modern extensions. This workshop presents an integrated overview of all these approaches.

Program outline

Day 1: Tests of neutral trait divergence (WL Chapter 12)
Lecture 1: Drift in the mean of quantitative traits
Lecture 2: Rate-based and time-series based tests
Lecture 3: Qst vs Fst
Lecture 4: Orr QTL tests (and their extensions)

Day 2: Tests based on Molecular Data I (WL Chapters 8, 9)
Lecture 5: Sweep theory
Lecture 6: Genomewide signatures from repeated past selection
Lecture 7: Polymorphismbased tests 1: Allele frequency changes and Lewontin-Krakauer tests
Lecture 8: Polymorphismbased tests 2: Genome pattern-based tests and SFS tests

Day 3: Tests based on Molecular Data II (WL Chapters 9, 10)
Lecture 9: Polymorphism-based tests 3: Haplotypebased tests
Lecture 10: Polymorphismbased tests 4: Domestication genes and other examples
Lecture 11: Divergencebased tests 1: HKA and MK tests
Lecture 12: Divergencebased tests 2: Rate of adaptive substitutions, Poisson random field models

Day 4: Estimating Individual fitness (WL Chapter 29)
Lecture 13: Episodes of Selection and the Assignment of Fitness
Lecture 14: Variance in Individual Fitness, Bateman gradients

Trait-fitness associations I (WL Chapter 29)
Lecture 15: Descriptions of Phenotypic Selection 1: Basics
Lecture 16: Descriptions of Phenotypic Selection 2: Fitness surfaces

Day 5: Trait-fitness associations II (WL Chapter 30)
Lecture 17: Multivariate selection 1: Basics
Lecture 18: Multivariate selection 2: Fitness surfaces
Lecture 19: Multivariate selection 3: Elasticities, path analysis, levels of selection
Lecture 20: wrap up and conclusions

Online

Full attendance and active participation

When?
September 6 to 10, 2021

Morning discussion 8:00-9:30 / Afternoon discussion 15:00-16:30

Where?
Online

We will adopt an hybrid setting for the course, see below


How?
Participants (on their own time) watch a total of three lectures for each day of discussion (6-10.09.2021), where we discuss two in the morning and one in the afternoon. These lectures will all be posted about a week before the course starts, so that students can begin to watch them on their own schedule ahead of the course. It will also include a welcome lecture and hints about how to watch the online lectures.The discussion format will be around 45 minutes of general questions, a 5 minute break, and then 30 minutes in breakout rooms (focused on specific questions/problems) with a general 10 minute discussion afterwards.

Questions?
Marta Bellone
@: [email protected]

Reimbursement:

Since the course will be online, no reimbursement of travel expenses can be claimed for the course

Through your myCUSO account!

Registrations are now open!

Priority is given to PhD students of the DPEE until 15 August 2021. After this deadline, first comes, first serves! 

Registration Fees:

Free for participants enrolled in the CUSO Ecology & Evolution doctoral program.
In case of cancellations, before the deadline: free
Late cancellations or no-show: Administrative fee of 100 CHF will be demanded
Other participants: please contact the program coordinator at ecologie-evolution(at)cuso.ch

20