Innate Immunity against Viruses

February 19, 2015

Caroline Tapparel

Prof. Caroline Tapparel,University of Geneva, Prof. Dominique Garcin, CMU University of Geneva Prof. Mirco Schmolke, CMU University of Geneva, Prof. Stefan Kunz, CHUV/UNIL

Marco Binder, German Cancer Research Center (DKFZ)Heidelberg and Heidelberg University, Germany

Matthias Schweizer, University of Bern, Switzerland

Martin Schwemmle, University of Freiburg, Germany

Völker Thiel, University of Bern, Switzerland

Research in fundamental virology represents an important interest within the CUSO network of research groups in microbial sciences. This one day workshop will cover current hot topics in basic virology and address the specific needs of our Ph.D. students in virology. State-of-the art lectures will be given by leading international and national experts and cover the newest developments of important aspects of basic virology research. In an interactive session during the afternoon, students will present their own research projects and discuss key issues of their own work with the experts. This will allow our PhD students to present their projects in front of a highly competent audience and to obtain valuable feedback from acclaimed experts in the field.

Program

Morning session

8:50                 Welcome and presentation of the program:       Mirco Schmolke  & Dominique Garcin

9:00 – 9:45      Marco Binder

                         Dynamics of Early Viral Replication and the Innate Antiviral Response-a Systems Approach

9:45 – 10:30   Martin Schwemmle 

                        Adaptation processes and innate immune responses in influenza A virus-infected hosts

Coffee break 10:30 – 11:00

11:00 – 11:45  Volker Thiel

                      To sense or not to sense viral RNA - essentials of coronavirus innate immune evasion

11:45 – 12:30 Matthias Schweizer

                      Pestivirus persistence: An example of innate immunotolerance

Lunch:   12:30 – 13:30

Afternoon session:

Presentation of key papers by groups of 2-3 participants

We recommend 20’ minutes for the presentation (short introduction, key results) with 20’ for discussion

13:30 – 14: 15             Presentation 1 with 5’ introduction by Völker Thiel 
                                     Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome
                                     activate RIG-I and antiviral signaling.” Weber et al., Cell Host Microbe. 2013;
                                    13(3):336-46

14:45 – 15: 30             Presentation 2  with 5’ introduction by  Martin Schwemmle
                                     Viral suppressors of the RIG-I-mediated interferon response are pre-packaged
                                     in influenza virions.” Lidemann et al., Nat. Commun. 2014; 9;5:5645

Coffee break 15:30 – 15:45

15:45 – 16:30              Presentation 3 with 5’ introduction by   Marco Binder
                                     Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.
                                     Wu et al., Mol Cell 2014; 55(4):511-23

16:30 – 17:15              Presentation 4 with 5’ introduction by Matthias Schweizer
                                     Failure to activate the IFN-beta promoter by a paramyxovirus lacking an
                                     interferon antagonist.” Killip et al., Virology 2011; 415:1, 39-46

17:15 – 17:30             Conclusion of the workshop

Program Flyer

CMU/UNIGE

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Location: Centre médical universitaire de Genève (CMU)

1 rue Michel Servet
7th floor, Bat C-D, Room 7172

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