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INVITED SEMINAR March 3, 2013 16h15-17h00 UNIL, Biophore, Auditorium SUMMARY Robustness is believed to be one of the major underlying properties of cellular networks, but its implementation in specific cases remains poorly understood. Using the bacterial chemotaxis network as a model system, we have analyzed robustness of its signaling output against two most common types of intra- and extracellular perturbations experienced by cellular networks. We demonstrated the pathway is indeed robust against the stochastic variation in protein levels, or gene expression noise, and that this robustness is inherent to the pathway topology. The pathway was further shown to be robust against variations of ambient temperature, whereby the effects of temperature on individual reactions are compensated at multiple levels.
AFTERNOON ROUND-TABLE DISCUSSION Tuesday March 4 Location: Biophore, Bio 2917.2, 13h00-14h30 Organizer: Prof. Victor Sourjik
1. Two papers for reading Kollmann, M., Lovdok, L., Bartholome, K., Timmer, J. & Sourjik, V. (2005). Design principles of a bacterial signalling network. Nature 438, 504-7. Oleksiuk, O., Jakovljevic, V., Vladimirov, N., Carvalho, R., Paster, E., Ryu, WS., Meir, Y., Wingreen, NS., Kollmann, M. and Sourjik, V. (2011). Thermal robustness of signaling in bacterial chemotaxis. Cell 145, 312-21. 2. Presentation and discussion of students' projects
3. General discussion
We will discuss the attached papers, principles of network analysis, synthetic biology and the students work. |
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